Justin Williams scored twice in the third period as the Hurricanes crushed the Penguins 6-2 at PPG Paints Arena.
Patrick Marleau and Evgeni Malkin scored for the Penguins, who held a 2-1 lead after the first.
Tristan Jarry allowed six goals for Pittsburgh, which has lost eight of 10.
The Pens will be on the road tomorrow as they visit the Devils in Newark.