The Giants missed a two-point try with 28 seconds left as the Buccaneers held on for a 25-23 win in East Rutherford.
Tom Brady threw for 279 yards and two touchdowns as Tampa Bay improved to 6-and-2.
Rob Gronkowski and Mike Evans each caught scores for the Bucs. Daniel Jones threw for two touchdowns and two interceptions as New York fell to 1-and-7.
Jones converted two fourth-down passes on the final drive before a 19-yard TD strike to Golden Tate.
Pass interference was initially flagged on the ensuing two-point try, but the refs then changed the call.
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