Jalen Ramsey and Taylor Rapp recorded interceptions as the Rams mauled the Bears 24-10 on Monday Night Football in Inglewood.
Leonard Floyd had two sacks for Los Angeles against his former team.
Jared Goff threw for two touchdowns while Malcolm Brown added a score on the ground as the Rams moved to 5-and-2.
Nick Foles threw two picks for Chicago, which fell to 5-and-2.
Eddie Jackson returned a fumble for the Bears' only touchdown in defeat.
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