Patrick Mahomes threw two second-half touchdown passes to help the Chiefs pull away for a 26-10 win over the Patriots at Arrowhead Stadium.
He hit Tyreek Hill from six yards out in the third quarter to make it 13-3 and found Mecole Hardman from six yards out in the fourth to make it 19-10.
Tyrann Mathieu sealed the win with a 25-yard pick-six on the next series as Kansas City improved to 4-and-0.
N'Keal Harry caught a four-yard touchdown pass from Jarrett Stidham early in the fourth to pull New England within 13-10.
Brian Hoyer started for the Pats, but he and Stidham combined for three interceptions and a lost fumble as New England fell to 2-and-2.
Cam Newton was out after testing positive for COVID-19.
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