The Indians have pushed their winning streak to a franchise-record 15 games as they drilled the White Sox 11-2 in Chicago.
Corey Kluber struck out 13 over seven innings of two-run ball to move to 15-and-4.
Erik Gonzalez homered twice, and Edwin Encarnacion, Francisco Lindor and Greg Allen also went deep for the Tribe.
Jose Abreu and Yolmer Sanchez homered in the first inning for the White Sox.
Mike Pelfrey tossed four innings of seven-run ball to fall to 3-and-11 with the loss.
Chicago is on a four-game slide.