Yanni Gourde scored in overtime to lift the Lightning to a 2-1 win over the Penguins in Pittsburgh.
Evgeni Malkin scored with the man advantage midway through the first to give the Penguins a 1-0 lead.
Pittsburgh has dropped two-of-three.
The Penguins will be back in action Friday when they host the Canadiens at PPG Paints Arena.